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Laboratoire de Biocatalyse, Bioremédiation et Métabolisme Synthétique

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Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

l2bms 16 June 2023 Biocatalysis Publications

Aurélie Fossey-Jouenne, Laurine Ducrot, P. J. Jongkind, Eddy Elisée, Anne Zaparucha, Gideon Grogan, Caroline E. Paul and Carine Vergne-Vaxelaire Front. Catal., 2023, Volume 3

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Expanding the Substrate Scope of Native Amine Dehydrogenases through In Silico Structural Exploration and Targeted Protein Engineering

l2bms 31 August 2022 Biocatalysis Publications

Laurine Ducrot, Megan Bennett, Dr. Gwenaëlle André-Leroux, Dr. Eddy Elisée, Sacha Marynberg, Aurélie Fossey-Jouenne, Prof. Anne Zaparucha, Prof. Gideon Grogan, Dr. Carine Vergne-Vaxelaire ChemCatChem, 2022,…

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Synthesis of Chiral Amines via a Bi-Enzymatic Cascade Using an Ene-Reductase and Amine Dehydrogenase

l2bms 21 January 2022 Biocatalysis Publications

Jongkind E., Fossey-Jouenne A., Mayol O., Zaparucha A., Vergne-Vaxelaire C., Paul E. ChemCatChem, 2022, Volume 14, Issue 2

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Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols

l2bms 26 November 2021 Biocatalysis Publications

Ducrot L., Bennett M., Caparco A., Champion J., Bommarius A., Zaparucha A., Grogan G., Vergne-Vaxelaire C. Front. Catal., 2021, 1

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Metagenomic Mining for Amine Dehydrogenase Discovery

l2bms 15 June 2020 Biocatalysis Publications

Caparco A., A.Pelletier E., Petit JL., Jouenne A., Bommarius B., de Berardinis V., Zaparucha A., Champion J., Bommarius A., Vergne-Vaxelaire C. Adv. Synth. Catal., 2020,…

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ATP regeneration system in chemoenzymatic amide bond formation with thermophilic CoA ligase

l2bms 20 February 2020 Biocatalysis Publications

Lelièvre C. M., Balandras M., Petit J.-L., Vergne-Vaxelaire C., Zaparucha A. ChemCatChem 2020, 12, 1184-1192

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A family of native amine dehydrogenases for the asymmetric reductive amination of ketones

l2bms 18 March 2019 Biocatalysis Publications

Mayol O., Bastard K., Beloti L., Frese A., Turkenburg J., Petit JL., Mariage A., Debard A., Pellouin V., Perret A., de Berardinis V., Zaparucha A.,…

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Method for preparing amines from aldehydes and ketones by biocatalysis

l2bms 10 January 2019 Patents

Inventor: Carine VERGNE-VAXELAIRE, Véronique De Berardinis, Anne Zaparucha WO2019008110A1

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Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family

l2bms 8 November 2018 Biocatalysis Publications

Bastard K., Isabet T., Stura E. A., Legrand P., Zaparucha A. Sci. Rep. 2018, 8:16587

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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

l2bms 16 February 2018 Biocatalysis Publications

Fossey-Jouenne A., Vergne-Vaxelaire C., Zaparucha A. J. Vis. Exp. 2018, 132

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Biocatalytic Approaches towards the Synthesis of Chiral Amino Alcohols from Lysine: Cascade Reactions Combining AlphaKetoAcid Oxygenase Hydroxylation with Pyridoxal Phosphate Dependent Decarboxylation

l2bms 2 May 2017 Biocatalysis Publications

Baud D., Peruch O., Saaidi P.-L., Fossey A., Mariage A., Petit J.-L., Salanoubat M., Vergne-Vaxelaire C., de Berardinis V., Zaparucha A. Adv. Syn. Catal. 2017,…

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Asymmetric reductive amination by a wild-type amine dehydrogenase from the thermophilic bacteria Petrotoga mobilis

l2bms 1 August 2016 Biocatalysis Publications

Mayol O., David S., Darii E., Debard A., Mariage A., Pellouin V., Petit JL., Salanoubat M., de Berardinis V., Zaparucha A., Vergne-Vaxelaire C. Catal. Sc.…

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New enzymes and method for preparing hydroxylated l-lysine or l-ornithine and analogs thereof

l2bms 4 June 2015 Patents

Inventor: Anne Zaparucha, Véronique De Berardinis, Pierre-Loïc Saaidi, Damien Baud WO2015078889A1

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Synthesis of Mono- and Dihydroxylated Amino Acids with New α-Ketoglutarate-Dependent Dioxygenases: Biocatalytic Oxidation of CH Bonds

l2bms 11 September 2014 Biocatalysis Publications

Baud D., Saaidi P.-L., Monfleur A., Harari M., Cuccaro J., Fossey A., Besnard M., Debard A., Mariage A., Pellouin V., Petit J.-L., Salanoubat M., Weissenbach…

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Large α-aminonitrilase activity screening of nitrilase superfamily members: Access to conversion and enantiospecificity by LC–MS

l2bms 1 June 2014 Biocatalysis Publications

Bordier F., Stam M., Darii E., Tricot S., Fossey A., Rohault J., Debard A., Mariage A., Pellouin V., Petit J.-L., Perret A., Vallenet D., Salanoubat…

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Nitrilase Activity Screening on Structurally Diverse Substrates: Providing Biocatalytic Tools for Organic Synthesis

l2bms 4 June 2013 Biocatalysis Publications

Vergne-Vaxelaire C, Bordier F., Fossey A., Besnard-Gonnet M., Debard A., Mariage A., Pellouin V., Perret A., Petit J.-L., Stam M., Salanoubat M., Weissenbach J., de…

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