Back
AmDH
- PI: Carine Vergne-Vaxelaire
We investigate amine dehydrogenases (AmDHs) with diverse substrates, properties, and structural features across biodiversity in order to provide the biocatalysis community with alternatives to other reported NAD(P)-dependent enzymes that also catalyze reductive amination.1
In collaboration with G. Grogan (University of York, UK) and teams from our research unit with expertise in bioinformatics (LABGeM, LAGE) and enzyme production (LGBM), we identified an AmDH family comprising more than 17,000 members. Their synthetic applications, in native or engineered form, are highly promising based on validations carried out at laboratory scale.2-10
This work is supported through the MODAMDH project (ANR-19-CE07-0007) and ALADIN (ESR/EquipEx+ ANR-21-ESRE-0021).