Projects

  • Identification of a new family of enzymes: amine dehydrogenases (AmDHs)
    21/06/2023

    We are looking for Amine dehydrogenases (AmDHs) with varied substrates/properties/structures within biodiversity…

  • CoA ligases for amide synthesis

    PI: Anne Zaparucha CoA ligases (EC 6.2.1.X) are ATP-dependent enzymes which catalyse the adenylation of carboxylic acids, followed by the conversion of the acyl adenylate…

  • α-kétoglutarate dependante Dioxygenases  (α-KetoAcid Oxygenases, αKAO)

    Oxidation reactions involving non-activated C-H bonds are among the most difficult to carry out in chemistry, but they are also among the most fundamental…

  • Nitrilases

    PI: Carine Vergne-Vaxelaire, Anne Zaparucha, Véronique De Berardinis The hydrolysis of nitriles into the corresponding carboxylic acids usually requires harsh acidic or basic conditions, which…

  • FAD-dépendante Halogenases

    PI: Anne Zaparucha Flavin-dependent halogenases (FHals) catalyse the halogenation of electron-rich substrates, mainly aromatics. Halogenated compounds have many applications, as pharmaceuticals, agrochemicals or as starting…

  • Transversal projects within the unit

    Circular carbon economy ALADIN (ESR/EquipEX+ ANR-21-ESRE-0021) Identification and assessment of the capacity of marine microbial bioresources to degrade UV sunscreens using in silico and experimental…